Changes

Once [[Lymphocytes#T Cells|T cells]] recognise antigen presence in the tissues, they go into action.  Their first response is always to recruit help, which is accomplished by returning to the nearest [[Lymph Nodes - Anatomy & Physiology|lymph node]] to carry out clonal expansion.  Daughter [[Lymphocytes#T Cells|T cells]] are created with identical TCRs in order to recognise the identified antigen.  These daughter cells are then returned to the circulation via the efferent lymph.   

Once [[Lymphocytes#T Cells|T cells]] recognise antigen presence in the tissues, they go into action.  Their first response is always to recruit help, which is accomplished by returning to the nearest [[Lymph Nodes - Anatomy & Physiology|lymph node]] to carry out clonal expansion.  Daughter [[Lymphocytes#T Cells|T cells]] are created with identical TCRs in order to recognise the identified antigen.  These daughter cells are then returned to the circulation via the efferent lymph.   

[[Lymphocytes#T Cells|T cells]] can differentiate three different ways, based on their Cluster of Differentiation (CD) number.  All [[Lymphocytes#T Cells|T cells]] are CD3⁺, and naive circulating [[Lymphocytes#T Cells|T cells]] will differentiate upon interaction with antigen to become either [[Lymphocytes#Cytotoxic CD8+|'''CD8⁺ (cytotoxic)''']] or [[Lymphocytes#Helper CD4+|'''CD4⁺ (helper)''']] [[Lymphocytes#T Cells|T cells]]. [[Lymphocytes#Helper CD4+|CD4⁺ T-cells]] will initially become CD4⁺-T_H0 cells, and must differentiate to [[T cell differentiation#TH1 Cells|T_H1]], [[T cell differentiation#TH2 Cells|T_H2]] or [[T cell differentiation#TH17 Cells|T_H17]] cells depending on the whim of the adaptive response.  T_H1,  T_H2 and T_H17 cells carry out different types of responses: T_H1 is responsible for enhancing the [[Macrophages|macrophage]] response, whereas T_H2 cells enhance the [[Lymphocytes#B Cells|B cell]] antibody production, and T_H17 cells enhance the innate immune response through increased granulocyte trafficking.  Typically, animals produce a balanced response of T_H cells, though this can lead to pathology, as can a skewed response, depending on the nature of the foreign organism.  For more on [[Lymphocytes#T Cells|T cell]] differentiation, see [[T cell differentiation|here]].

[[Lymphocytes#T Cells|T cells]] can differentiate three different ways, based on their Cluster of Differentiation (CD) number.  All [[Lymphocytes#T Cells|T cells]] are CD3⁺, and naive circulating [[Lymphocytes#T Cells|T cells]] will differentiate upon interaction with antigen to become either [[Lymphocytes#Cytotoxic CD8+|'''CD8⁺ (cytotoxic)''']] or [[Lymphocytes#Helper CD4+|'''CD4⁺ (helper)''']] [[Lymphocytes#T Cells|T cells]]. [[Lymphocytes#Helper CD4+|CD4⁺ T-cells]] will initially become CD4⁺-T_H0 cells, and must differentiate to [[T cell differentiation#TH1 Cells|T_H1]], [[T cell differentiation#TH2 Cells|T_H2]] or [[T cell differentiation#TH17 Cells|T_H17]] cells depending on the whim of the adaptive response (T_H17cells are a recent addition to this model, with research still being conducted into function).  T_H1,  T_H2 and T_H17 cells carry out different types of responses: T_H1 is responsible for enhancing the [[Macrophages|macrophage]] response, whereas T_H2 cells enhance the [[Lymphocytes#B Cells|B cell]] antibody production, and T_H17 cells enhance the innate immune response through increased granulocyte trafficking.  Typically, animals produce a balanced response of T_H cells, though this can lead to pathology, as can a skewed response, depending on the nature of the foreign organism.  For more on [[Lymphocytes#T Cells|T cell]] differentiation, see [[T cell differentiation|here]].

*''[[Lymphocytes#B Cells|B cell]] response''

*''[[Lymphocytes#B Cells|B cell]] response''