Changes

<p>Mast cells are derived from the same stem cell line as [[Basophils|basophils]] and while they are similar to basophils they are not identical. Mast cells are found in connective tissue and are larger than other [[Leukocytes|leukocytes]] at 15-20µm. They have cytoplasm containing a high number of large, intensely staining basophilic granules which mask the nucleus.</p>

<p>Mast cells are derived from the same stem cell line as [[Basophils|basophils]] and while they are similar to basophils they are not identical. Mast cells are found in connective tissue and are larger than other [[Leukocytes|leukocytes]] at 15-20µm. They have cytoplasm containing a high number of large, intensely staining basophilic granules which mask the nucleus.</p>

==Development==

==Development==

<p>Mast cells colony forming units (CFU) develop in the [[Bone Marrow - Anatomy & Physiology|bone marrow]] from the myeloid set cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) under the stimulation of IL-3 and Stem Cell Factor. Then under the stimulation of Il-6 and SCF the immature mast cells are formed. These then enter circulation where they remain undifferentiated. On migration into tissue they then differentiate, under stimulation by Il-4, and produce their granules. Once in the tissue mast cells may last for weeks to months.</p>

<p>Mast cells colony forming units (CFU) develop in the [[Bone Marrow - Anatomy & Physiology|bone marrow]] from the myeloid stem cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) under the stimulation of IL-3 and Stem Cell Factor (SCF). Then under the continual stimulation with SCF, and with the additional stimulation with IL-6, the immature mast cells are formed. These then enter circulation where they remain undifferentiated. On migration into tissue they then differentiate, under stimulation by IL-4, and produce their granules. Once in the tissue mast cells may last for weeks to years.</p>

==Granules==

==Granules==