Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody, with binding to Fcε receptors before it can bind to the target, and is found in low levels in blood plasma. Like [[IgA]], it is produced by plasma cells and is mainly localised to mucosal surfaces.
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Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody, with binding to Fcε receptors before it can bind to the target, and is found in low levels in blood plasma. Like [[IgA]], it is produced by [[B cell Differentiation|plasma cells]] and is mainly localised to mucosal surfaces.