Changes

*Alpha-haemolysin may increase iron availability for invading organisms

*Alpha-haemolysin may increase iron availability for invading organisms

*Siderophores are made by certain pathogenic strains, and are responsible for iron aquisition; they include aerobactin and enterobactin

*Siderophores are made by certain pathogenic strains, and are responsible for iron aquisition; they include aerobactin and enterobactin

===Extra-intestinal infection===

===Extra-intestinal infection===

***Ammonia, dust, viral infections and temperature changes enhance likelihood of disease

***Ammonia, dust, viral infections and temperature changes enhance likelihood of disease

===Intestinal disease===

 

===Intestinal infection===

*''E. coli'' is part of the flora of the large intestine, but is not usually found in the small intestine

*''E. coli'' is part of the flora of the large intestine, but is not usually found in the small intestine