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***This causes irreversible activation of adenylate cyclase in target cells
***This causes irreversible activation of adenylate cyclase in target cells
***This raises the cAMP level and causes hypersecretion of water and chloride ions into the lumen of the small intestine and inhibits reabsorption of sodium
***This raises the cAMP level and causes hypersecretion of water and chloride ions into the lumen of the small intestine and inhibits reabsorption of sodium
***ST activates guanylate cyclase in enteric epithelial cells, stimulating fluid secretion
**Clinical signs:
**Clinical signs:
***The gut becomes distended with fluid and a [[Intestines - diarrhoea#Secretory Diarrhoeas|secretory diarrhoea]] which lasts several days results
***The gut becomes distended with fluid and a [[Intestines - diarrhoea#Secretory Diarrhoeas|secretory diarrhoea]] which lasts several days results
***Parenteral vaccination of pigs and cattle protects offspring from scours via antibody production in the colostrum (passive immunity)
***Parenteral vaccination of pigs and cattle protects offspring from scours via antibody production in the colostrum (passive immunity)
***ST is not immunogenic; it is small, with only 19 amino acids
***ST is not immunogenic; it is small, with only 19 amino acids
*Enteropathogenic ''E. coli'' (EPEC):
*Enteropathogenic ''E. coli'' (EPEC):
**Possess ''E. coli'' adherence factor plasmid
**Possess ''E. coli'' adherence factor plasmid
**Cause attching and effacing lesions in the gut, with necrosis of enterocytes and stunting and fusion of villi
**Cause attching and effacing lesions in the gut, with necrosis of enterocytes and stunting and fusion of villi
*Enteroinvasive ''E. coli'':
*Enteroinvasive ''E. coli'':
**Bacteraemia and septicaemia
**Dysentry-like strains
**Dysentry-like strains
**Invade epithelial cells by inducing endocytosis
**Invade epithelial cells by inducing endocytosis