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***Virulence related to adhesive properties, complement resistance and ability for iron aquisition
***Virulence related to adhesive properties, complement resistance and ability for iron aquisition
***Ammonia, dust, viral infections and temperature changes enhance likelihood of disease
***Ammonia, dust, viral infections and temperature changes enhance likelihood of disease
*Oedema disease of pigs:
**Oedema disease of pigs:
**Acute, frequently fatal enterotoxaemia of weaned pigs
***Acute, frequently fatal enterotoxaemia of weaned pigs
**Associated with particular haemolytic serotypes of ''E. coli''
***Associated with particular haemolytic serotypes of ''E. coli''
**Verotoxin (Shiga toxin II e) released in the small intestine and carried in the bloodstream
***Verotoxin (Shiga toxin II e) released in the small intestine and carried in the bloodstream
**Haemolysin production
***Haemolysin production
**Subcutaneous and subserosal oedema
***Subcutaneous and subserosal oedema
**Peracute disease affecting particulary healthy piglets
***Peracute disease affecting particulary healthy piglets
**Mortality rate 30%-90%
***Mortality rate 30%-90%
**Antimicrobial treatment effective if administered in time
***Antimicrobial treatment effective if administered in time
**Watery mouth of lambs:
***Affects lambs under three days old
***Lack of colostrum allows collonisation and overgrowth of ''E. coli'' in the small intestine
***Systemic invasion by ''E. coli''
***Absorption of endotoxin leads to death
***Severe depression, anorexia, salivation and abdominal distension
***Morbidity and mortality high
**Infrequently cause diarrhoea in calves, pigs and humans
**Infrequently cause diarrhoea in calves, pigs and humans
**Important virulence factors include toxin and fimbriae
**Important virulence factors include toxin and fimbriae