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Also known as: '''''Theiler's disease — ESH

Also known as: '''''Theiler's disease — ESH

==Introduction==

==Introduction==

Equine Serum Hepatitis (ESH) is the most common cause of acute hepatitis in horses. It is often associated with prior administration of an equine biologic product, most commonly tetanus antitoxin (TAT). In some cases, the affected horse may not have received the antitoxin but may have been in contact with another horse that received TAT. Other biologic products that have been implicated include encephalitis vaccines and equine serum. Other aetiologies such as alkaloid toxicity and mycotoxins have been reported. Several cases have been reported occurring in groups of horses in which no biologic product had been administered, indicating that there may be an infectious or viral component to the disease.  A Type III (immune-complex mediated) hypersensitivity reaction has also been proposed.  

Equine Serum Hepatitis (ESH) is the most common cause of acute hepatitis in horses. It is often associated with prior administration of an equine biologic product, most commonly tetanus antitoxin (TAT). In some cases, the affected horse may not have received the antitoxin but may have been in contact with another horse that received TAT. Other biologic products that have been implicated include encephalitis vaccines and equine serum. Other aetiologies such as alkaloid toxicity and mycotoxins have been reported. Several cases have been reported occurring in groups of horses in which no biologic product had been administered, indicating that there may be an infectious or viral component to the disease.  A [[Type III Hypersensitivity|Type III (immune-complex mediated) hypersensitivity]] reaction has also been proposed.  

==Signalment==

==Signalment==

Use of tetanus antitoxin in pregnant mares should be avoided. TAT should only be adminstered to horses with an unknown or absent tetanus toxoid vaccination history.

Use of tetanus antitoxin in pregnant mares should be avoided. TAT should only be adminstered to horses with an unknown or absent tetanus toxoid vaccination history.

[[File:CABI logo.jpg|left|90px]]

|literature search = [http://www.cabdirect.org/search.html?q=%28%28title%3A%28%22serum+hepatitis%22%29+AND+od%3A%28horses%29%29%29+OR+%28%28title%3A%28%22Theiler%27s+disease%22%29%29%29 Equine Serum Hepatitis publications]

 

 

[http://www.cabdirect.org/search.html?q=%28%28title%3A%28%22serum+hepatitis%22%29+AND+od%3A%28horses%29%29%29+OR+%28%28title%3A%28%22Theiler%27s+disease%22%29%29%29 Equine Serum Hepatitis publications]

==References==

==References==

[[Category:Liver_-_Inflammatory_Pathology]]

[[Category:Liver_-_Inflammatory_Pathology]]