Changes

Fixed liver samples can be '''immunostained''' and sera from aborted animals examined to confirm viral presence and are both simple and sensitive.  

Fixed liver samples can be '''immunostained''' and sera from aborted animals examined to confirm viral presence and are both simple and sensitive.  

'''IgM [[ELISA testing |ELISA]]''' can also be performed on serum.

'''IgM [[ELISA testing |ELISA]]''' can also be performed on serum. Virus neutralisation is the prescribed test for international trading of animals.

On '''necropsy''', in the viraemic stage, widespread '''petechiae and ecchymoses''' on serous surfaces and organs will be seen and '''extravasated blood''' present in the body cavities.  

On '''necropsy''', in the viraemic stage, widespread '''petechiae and ecchymoses''' on serous surfaces and organs will be seen and '''extravasated blood''' present in the body cavities.  

In older animals, the liver is enlarged and inflamed, with many '''foci of necrosis''' which are bronzed and jaundiced. The gall bladder may also be distended and haemorrhagic. Lymph nodes are enlarged and their germinal centres may be necrotic on closer examination. Extensive subcapsular haemorrhage in the spleen is usual. Renal changes include oedema and congestion. Epicardial and endocardial haemorrhages are often present on the heart.

In older animals, the liver is enlarged and inflamed, with many '''foci of necrosis''' which are bronzed and jaundiced. The gall bladder may also be distended and haemorrhagic. Lymph nodes are enlarged and their germinal centres may be necrotic on closer examination. Extensive subcapsular haemorrhage in the spleen is usual. Renal changes include oedema and congestion. Epicardial and endocardial haemorrhages are often present on the heart.

==Treatment==

==Treatment==