Neonatal isoerythrolysis is a disease of humans and domestic animals and has been most commonly observed in newborn cats and horses. Rarely it has also been described in other species following [[:Category:Transfusion Medicine|blood transfusions]], [[Vaccines|vaccination]] or previous pregnancy. The disease is characterised by [[Immune Mediated Haemolytic Anaemia|immune-mediated haemolytic anaemia]] due to ingestion of maternal colostral antibody directed against surface antigens on neonatal red blood cells. This leads to a [[Type II Hypersensitivity|type II hypersensitivity]] reaction causing extravascular and intravascular haemolysis during the first few days of life. | Neonatal isoerythrolysis is a disease of humans and domestic animals and has been most commonly observed in newborn cats and horses. Rarely it has also been described in other species following [[:Category:Transfusion Medicine|blood transfusions]], [[Vaccines|vaccination]] or previous pregnancy. The disease is characterised by [[Immune Mediated Haemolytic Anaemia|immune-mediated haemolytic anaemia]] due to ingestion of maternal colostral antibody directed against surface antigens on neonatal red blood cells. This leads to a [[Type II Hypersensitivity|type II hypersensitivity]] reaction causing extravascular and intravascular haemolysis during the first few days of life. |