Changes

Caused by: '''''Clostridium piliforme'''''

Caused by: '''''Clostridium piliforme'''''

The aetiology of the disease is poorly understood. Infection most likely results from oral exposure to spores; possible mechanisms include ingestion of spore-forming faeces or contact with carrier animals. Following ingestion, the spores colonise the intestine and liver via the portal circulation. Dissemination to the hepatocytes, enterocytes and myocytes then occurs.

The aetiology of the disease is poorly understood. Infection most likely results from oral exposure to spores; possible mechanisms include ingestion of spore-forming faeces or contact with carrier animals. Following ingestion, the spores colonise the intestine and liver via the portal circulation. Dissemination to the hepatocytes, enterocytes and myocytes then occurs.

==Clinical signs==

==Clinical Signs==

The disease in rabbits and rodents is usually characterised by an unkempt coat, depression and fatal diarrhoea. Foals are usually aged between one and six weeks of age and are often clinically normal at birth. Rapidly progressive clinical signs relating to an acute hepatitis then develop. Clinical signs include acute lethargy, loss of suckle reflex, severe icterus, neurological signs (such as head pressing or circling), pyrexia and diarrhoea. Animals may be found dead without known pre-existing clinical signs. The course of the disease from the onset of clinical signs to death is usually around 48 hours.  

The disease in rabbits and rodents is usually characterised by an unkempt coat, depression and fatal diarrhoea. Foals are usually aged between one and six weeks of age and are often clinically normal at birth. Rapidly progressive clinical signs relating to an acute hepatitis then develop. Clinical signs include acute lethargy, loss of suckle reflex, severe icterus, neurological signs (such as head pressing or circling), pyrexia and diarrhoea. Animals may be found dead without known pre-existing clinical signs. The course of the disease from the onset of clinical signs to death is usually around 48 hours.  

<big>'''Also see [[Tyzzer's Disease - Rabbit]].'''</big>

<big>'''Also see [[Tyzzer's Disease - Rabbit]].'''</big>

[[File:CABI logo.jpg|left|90px]]

|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Tyzzer%27s+disease%22&occuring1=title&rowId=2&options2=AND&q2=horses&occuring2=od&rowId=3&options3=AND&q3=&occuring3=freetext&x=42&y=10&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Tyzzer's disease in horses]

 

 

[http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Tyzzer%27s+disease%22&occuring1=title&rowId=2&options2=AND&q2=horses&occuring2=od&rowId=3&options3=AND&q3=&occuring3=freetext&x=42&y=10&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Tyzzer's disease in horses]

[http://www.cabdirect.org/search.html?q=title%3A%28%22Tyzzer%27s+disease%22%29+AND+%28od%3A%28rodents%29+OR+od%3A%28rats%29+OR+od%3A%28mice%29+OR+od%3A%28rabbits%29%29 Tyzzer's disease in rodents and rabbits]

[http://www.cabdirect.org/search.html?q=title%3A%28%22Tyzzer%27s+disease%22%29+AND+%28od%3A%28rodents%29+OR+od%3A%28rats%29+OR+od%3A%28mice%29+OR+od%3A%28rabbits%29%29 Tyzzer's disease in rodents and rabbits]

[http://www.cabdirect.org/search.html?q=title%3A%28%22Bacillus+piliformis%22%29+OR+title%3A%28%22Clostridium+piliforme+%22%29 ''Bacillus piliformis/Clostridium piliforme'' publications]

[http://www.cabdirect.org/search.html?q=title%3A%28%22Bacillus+piliformis%22%29+OR+title%3A%28%22Clostridium+piliforme+%22%29 ''Bacillus piliformis/Clostridium piliforme'' publications]

==References==

==References==

{{review}}

{{review}}

[[Category:Hepatitis,_Bacterial]][[Category:Rodent - Alimentary System]][[Category:Liver Diseases - Horse]]

[[Category:Hepatitis,_Bacterial]][[Category:Rodent - Alimentary System]][[Category:Liver Diseases - Horse]]

[[Category:Expert_Review]]

[[Category:Expert_Review]]