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Porcine Juvenile Pustular Psoriasiform Dermatitis (view source)
Revision as of 11:46, 28 February 2008
, 11:46, 28 February 2008New page: <big><center>'''BACK TO SKIN - CONGENITAL'''</center></big> ==Porcine Juvenile Pustular Psoriasiform Dermatitis (P...
<big><center>[[Skin - congenital#Porcine Juvenile Pustular Psoriasiform Dermatitis|'''BACK TO SKIN - CONGENITAL''']]</center></big>
==Porcine Juvenile Pustular Psoriasiform Dermatitis (Pityriasis rosea)==
===General===
*Pityriasis rosea is a self‑limiting inflammatory disease of young pigs.
*The disease is of unknown etiology.
*There is a predilection for the white breeds, especially the Landrace, and suggestions of a hereditary link.
**Although the mode of inheritance is not simple, it is clear that swine that have had this condition are more likely to produce affected progeny.
*The condition is noncontagious.
**Experimental attempts at transmitting the disease, and attempts to demonstrate any significant microorganisms have failed.
**The disease has been observed in cesarean‑derived SPF pigs.
*The condition most frequently occurs in young pigs, 3‑14 weeks of age, and often more than one member of a litter is affected.
*'''Although this condition had been previously called pityriasis rosea, clinically and pathologically it is nothing like pityriasis rosea in humans!'''
===Clinical Signs===
*There are usually no systemic signs. Skin lesions may be preceded by anorexia, vomiting, & diarrhea.
*There is no fever.
===Gross Lesions===
*Primary lesions are seen on the ventral abdomen or medial thighs, and appear as symmetric, sharply defined, red raised plaques up to 6 mm in diameter.
*These expand centrifugally, often coalescing to produce whorling mosaic or serpiginous patterns, and may extend up the sides and perineum.
*As they expand, lesions become scaly and heal from the center outward, producing ring‑shaped lesions with a center of scaly or normal appearing skin surrounded by a zone of elevated erythematous skin and scales.
**The term pseudo-ringworm has been used to describe this condition.
*Lesions are nonirritant and usually resolve spontaneously in 2 ‑ 10 weeks.
===Microscopic Lesions===
*Skin biopsy reveals superficial perivascular dermatitis with psoriasiform epidermal hyperplasia.
*The superficial dermis usually shows mild to moderate mucinous degeneration, and eosinophils and neutrophils are the predominant inflammatory cell types.
*Intra-epidermal pustules containing eosinophils and neutrophils are prominent in early lesions.
*Parakeratotic hyperkeratosis is usually prominent.
===Differential Diagnosis===
#Dermatophytosis ‑ (etio: Tr. mentagrophytes, M. canis, Tr. verrucosum var. discoides, M. nanum, Tr. rubrum) Ruled‑out due to lack of mycotic organisms.
#Exudative epidermitis (greasy pig disease) ‑ (''Staphylococcus hyicus'') Early lesions may appear as red plaques, but soon become exudative and ulcerated; R/O based on culture, lesion distribution, histopathology.
#Dermatosis vegetans ‑ Systemic, erythematous maculopapular dermatitis caused by the inheritance of a autosomal recessive, semilethal factor. Skin, coronary band and hoof lesions, giant cell pneumonia, fatal.
#Swinepox ‑ Ballooning degeneration and intracytoplasmic inclusion bodies.
===Postgraduate===
Kate
::''IL-3 is involved... Vet Path (2007) 34: 45-43''
==Porcine Juvenile Pustular Psoriasiform Dermatitis (Pityriasis rosea)==
===General===
*Pityriasis rosea is a self‑limiting inflammatory disease of young pigs.
*The disease is of unknown etiology.
*There is a predilection for the white breeds, especially the Landrace, and suggestions of a hereditary link.
**Although the mode of inheritance is not simple, it is clear that swine that have had this condition are more likely to produce affected progeny.
*The condition is noncontagious.
**Experimental attempts at transmitting the disease, and attempts to demonstrate any significant microorganisms have failed.
**The disease has been observed in cesarean‑derived SPF pigs.
*The condition most frequently occurs in young pigs, 3‑14 weeks of age, and often more than one member of a litter is affected.
*'''Although this condition had been previously called pityriasis rosea, clinically and pathologically it is nothing like pityriasis rosea in humans!'''
===Clinical Signs===
*There are usually no systemic signs. Skin lesions may be preceded by anorexia, vomiting, & diarrhea.
*There is no fever.
===Gross Lesions===
*Primary lesions are seen on the ventral abdomen or medial thighs, and appear as symmetric, sharply defined, red raised plaques up to 6 mm in diameter.
*These expand centrifugally, often coalescing to produce whorling mosaic or serpiginous patterns, and may extend up the sides and perineum.
*As they expand, lesions become scaly and heal from the center outward, producing ring‑shaped lesions with a center of scaly or normal appearing skin surrounded by a zone of elevated erythematous skin and scales.
**The term pseudo-ringworm has been used to describe this condition.
*Lesions are nonirritant and usually resolve spontaneously in 2 ‑ 10 weeks.
===Microscopic Lesions===
*Skin biopsy reveals superficial perivascular dermatitis with psoriasiform epidermal hyperplasia.
*The superficial dermis usually shows mild to moderate mucinous degeneration, and eosinophils and neutrophils are the predominant inflammatory cell types.
*Intra-epidermal pustules containing eosinophils and neutrophils are prominent in early lesions.
*Parakeratotic hyperkeratosis is usually prominent.
===Differential Diagnosis===
#Dermatophytosis ‑ (etio: Tr. mentagrophytes, M. canis, Tr. verrucosum var. discoides, M. nanum, Tr. rubrum) Ruled‑out due to lack of mycotic organisms.
#Exudative epidermitis (greasy pig disease) ‑ (''Staphylococcus hyicus'') Early lesions may appear as red plaques, but soon become exudative and ulcerated; R/O based on culture, lesion distribution, histopathology.
#Dermatosis vegetans ‑ Systemic, erythematous maculopapular dermatitis caused by the inheritance of a autosomal recessive, semilethal factor. Skin, coronary band and hoof lesions, giant cell pneumonia, fatal.
#Swinepox ‑ Ballooning degeneration and intracytoplasmic inclusion bodies.
===Postgraduate===
Kate
::''IL-3 is involved... Vet Path (2007) 34: 45-43''