Changes

** Type A and C peripheral nociceptors are sensitised due to inflammatory mediators released by tissue damage. This lowers the response threshold of the receptors, or a greater response to the same stimulus is produced. Both mechanisms may work in conjunction.

** Type A and C peripheral nociceptors are sensitised due to inflammatory mediators released by tissue damage. This lowers the response threshold of the receptors, or a greater response to the same stimulus is produced. Both mechanisms may work in conjunction.

* Centrally, giving '''central sensitisation'''.

* Centrally, giving '''central sensitisation'''.

** The exictability of spinal nociceptive neurons is enhanced, giving a hypersensitive and hyperactice nociceptive transmission system.

** The excitability of spinal nociceptive neurons is enhanced, giving a hypersensitive and hyperactive nociceptive transmission system.

** Central sensitisation may be short-lived when it is associated with transient changes in neurotransmitter activity.

** Central sensitisation may be short-lived when it is associated with transient changes in neurotransmitter activity.

** Central sensitisation may be long-lived when it is associated with phenotypic changes in central neurons.

** Central sensitisation may be long-lived when it is associated with phenotypic changes in central neurons.