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Equine Spleen - Horse Anatomy (view source)
Revision as of 17:01, 28 November 2012
, 17:01, 28 November 2012Created page with "{{unfinished}} ==Introduction== The spleen is a major lymphoid and blood filtration organ and is located in the left cranial abdomen. It is responsible for storing and removin..."
{{unfinished}}
==Introduction==
The spleen is a major lymphoid and blood filtration organ and is located in the left cranial abdomen. It is responsible for storing and removing [[Erythrocytes|erythrocytes]] from the blood as well as antigen surveillance of the blood and antibody production.
==Structure==
{|align="right"
|[[Image:LH_Spleen_Equine_Ultrasound.jpg|150px]]
|[[Image:LH_Spleen_Histology.jpg|150px]]
|-
!<p>Normal Ultrasound</p> (Equine)
!Histological section
|-
|colspan="2"|<center><sup>©Nottingham Uni 2008 </sup></center>
|}
The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the [[Equine Alimentary System - Horse Anatomy#Stomach|stomach]] by the '''gastrosplenic ligament'''. The spleen is enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae.
The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp, which are separated by the marginal sinus.
===Red Pulp===
The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain [[Macrophages|macrophages]], [[B cell differentiation#Plasma cells|plasma cells]], [[Lymphocytes - Introduction|lymphocytes]] and other mature blood cells e.g. [[Blood Cells - Overview|granulocytes]] and [[Erythrocytes|erythrocytes]]. While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls.
===White Pulp===
White pulp is organised in relation to the splenic arterioles and consists of discrete lymphoid tissue surrounding a central arteriole. There is a sheath of [[Lymphocytes#T cells|T cells]] directly around the arteriole, the periarteriolar lymphoid sheath (PALS), which is surrounded by a marginal sinus, and then a zone of [[Lymphocytes#B cells|B cells]] and [[Macrophages|macrophages]] (the marginal zone). B cell follicles are associated with the marginal zone and expand and develop germinal centres after antigen activation. The marginal sinuses are linked to the red pulp sinuses. White pulp stains basophilic in a H&E stain.
==Introduction==
The spleen is a major lymphoid and blood filtration organ and is located in the left cranial abdomen. It is responsible for storing and removing [[Erythrocytes|erythrocytes]] from the blood as well as antigen surveillance of the blood and antibody production.
==Structure==
{|align="right"
|[[Image:LH_Spleen_Equine_Ultrasound.jpg|150px]]
|[[Image:LH_Spleen_Histology.jpg|150px]]
|-
!<p>Normal Ultrasound</p> (Equine)
!Histological section
|-
|colspan="2"|<center><sup>©Nottingham Uni 2008 </sup></center>
|}
The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the [[Equine Alimentary System - Horse Anatomy#Stomach|stomach]] by the '''gastrosplenic ligament'''. The spleen is enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae.
The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp, which are separated by the marginal sinus.
===Red Pulp===
The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain [[Macrophages|macrophages]], [[B cell differentiation#Plasma cells|plasma cells]], [[Lymphocytes - Introduction|lymphocytes]] and other mature blood cells e.g. [[Blood Cells - Overview|granulocytes]] and [[Erythrocytes|erythrocytes]]. While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls.
===White Pulp===
White pulp is organised in relation to the splenic arterioles and consists of discrete lymphoid tissue surrounding a central arteriole. There is a sheath of [[Lymphocytes#T cells|T cells]] directly around the arteriole, the periarteriolar lymphoid sheath (PALS), which is surrounded by a marginal sinus, and then a zone of [[Lymphocytes#B cells|B cells]] and [[Macrophages|macrophages]] (the marginal zone). B cell follicles are associated with the marginal zone and expand and develop germinal centres after antigen activation. The marginal sinuses are linked to the red pulp sinuses. White pulp stains basophilic in a H&E stain.