Changes

====Case-control studies====

====Case-control studies====

Case-control studies are based upon the identification of two populations of individuals - one ('cases') comprising those who have experienced the outcome of interest (e.g. disease) and one ('controls') comprising those who have not experienced the outcome of interest (but who are otherwise comparable to the cases). As the outcome itself is involved in the selection of participants, no measures of disease frequency can be made from a case-control study, which are only used for the identification of exposures associated with disease (through the estimation of 'odds ratios'). Although case-control studies can be very useful in the investigation of rare diseases, there can be considerable difficulties in ensuring that the control group are comparable to the case group. If these groups are not comparable, there can be considerable selection bias, which an invalidate the results of the study.

Case-control studies are based upon the identification of two populations of individuals - one ('cases') comprising those who have experienced the outcome of interest (e.g. disease) and one ('controls') comprising those who have not experienced the outcome of interest (but who are otherwise comparable to the cases). As the outcome itself is involved in the selection of participants, no measures of disease frequency can be made from a case-control study, which are only used for the identification of exposures associated with disease (through the estimation of 'odds ratios'). Although case-control studies can be very useful in the investigation of rare diseases, there can be considerable difficulties in ensuring that the control group are comparable to the case group. If these groups are not comparable, there can be considerable selection bias, which can invalidate the results of the study.

===Experimental studies===

===Experimental studies===

In experimental studies (also known as '''intervention studies'''), the investigator allocates the exposure of interest to a selection of the participants prior to following them up. The allocation of the exposure should be randomised, and there should be a clear control group which does not receive the exposure (known as a '''Randomised Controlled Trial'''). Ideally, 'blinding' of participants and investigators to the treatment allocation should also be performed whenever possible in order to reduce any differences between the groups. As biases and confounding are reduced through the randomised allocation of exposure, these studies provide the best quality of evidence of any single study type. However, in a similar fashion to cohort studies, they can be very costly, both in terms of money and time. Additionally, in the case of suspected harmful exposures, randomised controlled trials may not be an ethical option, and so they are commonly used when investigating interventions which are suspected to be beneficial.

In experimental studies (also known as '''intervention studies'''), the investigator allocates the exposure of interest to a selection of the participants prior to following them up. The allocation of the exposure should be randomised, and there should be a clear control group which does not receive the exposure (known as a '''Randomised Controlled Trial'''). Ideally, 'blinding' of participants and investigators to the treatment allocation should also be performed whenever possible in order to reduce any differences between the groups. As biases and confounding are reduced through the randomised allocation of exposure, these studies provide the best quality of evidence of any single study type. However, in a similar fashion to cohort studies, they can be very costly, both in terms of money and time. Additionally, in the case of suspected harmful exposures, randomised controlled trials may not be an ethical option, and so they are commonly used when investigating interventions which are suspected to be beneficial.