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===Pathogenesis and pathogenicity===
===Pathogenesis and pathogenicity===
*Pyogenic causing
*Pyogenic causing suppurative infections except for ''C. bovis''
*''C. bovis'' causes mild neutrophil response in teat canal of healthy dairy cows and may protect from more pathogenic bacteria
*''C. pseudotuberculosis'':
**Facultative intracellular pathogen inside macrophages
**Cell wall lipid
**Produces a phospholipase toxin which hydolyses sphingomyelin in mammalian cell membranes
**Phospholipase may enhance survival and multiplication in host in early stages
*''C. renale''
**Urinary tract pathogens
**Produce urease and hydrolyse urea
**Possess fimbriae for attachment to urogenital mucosa
**Infection when immunity reduced or following tissue damage during parturition
*Infection follows tissue trauma
*Infection follows tissue trauma
*''C. pseudotuberculosis'' casues caseous lymphadenitis in sheep
*''C. pseudotuberculosis'' casues caseous lymphadenitis in sheep
*Carried on skin of sheep
*Carried on skin of sheep
*Infection through shearing wounds
*Infection through shearing wounds
*Ulcerative lymphangitis in horses
*Ulcerative lymphangitis in horses