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*Neurotoxic clostridia, ''Clostridium tetani'' and ''Clostridium botulinum'' affect neuromuscular function but cause no tissue damage
*Neurotoxic clostridia, ''Clostridium tetani'' and ''Clostridium botulinum'' affect neuromuscular function but cause no tissue damage
*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemia
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemias in sheep
===Characteristics===
===Characteristics===
===Pathogenesis and pathogenicity===
===Pathogenesis and pathogenicity===
*Produce extracellular digestive enzymes and toxic substance known as exotoxins
*Exotoxins cause necrosis, haemolysis and death
*Collagenase, hyaluronidase and DNase enymes facilitate spread through tissues