Changes

==Mechanism of Action==

==Mechanism of Action==

Propofol acts upon the GABAa receptors, causing it's activation, similarly to [[#barbituates|thiopental]], although it binds at a different site. This causes increased chloride conductance leading to hyperpolarisation.  

Propofol binds to and activates  GABA-A receptors, similarly to [[#barbituates|thiopental]], benzodiazepines and alcohol, although it binds at a different site on this complex multi-subunit receptor. GABA is a major inhibitory neurotransmitter in the CNS. Activation of the GABA-A receptor causes increased chloride conductance leading to hyperpolarisation of the postsynaptic neuronal cell membrane, thus inhibiting conductance producing depression of the CNS.

 

==Pharmacological Considerations==

==Pharmacological Considerations==