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→Specific Effects on Anxiety and Panic
==Specific Effects on Anxiety and Panic==
==Specific Effects on Anxiety and Panic==
Panic is a special manifestation of anxiety and the mechanism of action of drugs that reduce panic share a common factor. This means that only drugs that reduce the firing rate of neurons in the Locus Coeruleus [LC] effectively reduce panic. For those drugs that do affect the firing rate of the LC, this is thought to be a key to their mode of action in reducing anxiety.
Panic is a special manifestation of anxiety and the mechanism of action of drugs that reduce panic share a common factor. This means that only drugs that reduce the firing rate of neurons in the Locus Coeruleus (LC) effectively reduce panic. For those drugs that do affect the firing rate of the LC, this is thought to be a key to their mode of action in reducing anxiety.
Numerous models of anxiety have been tested in animals. Many are not apparently reliable detectors of anxiolytic effect, and have not been applied to more modern anxiolytic/antidepressant drugs like SSRIs/SRIs. Those in which there is a response to TCA/SRI and SSRI drugs are:
Numerous models of anxiety have been tested in animals. Many are not apparently reliable detectors of anxiolytic effect, and have not been applied to more modern anxiolytic/antidepressant drugs like SSRIs/SRIs. Those in which there is a response to TCA/SRI and SSRI drugs are: