Due to the long half-life of fluoxetine it is not necessary to gradually reduce or taper the dose. Once treatment with fluoxetine has ceased continued behavioural modification is advisable to avoid the reappearance of clinical signs. The long half-life of fluoxetine and its metabolites also mean that a period of at least 6 weeks should be allowed to pass before administration of any drugs which may interact adversely. | Due to the long half-life of fluoxetine it is not necessary to gradually reduce or taper the dose. Once treatment with fluoxetine has ceased continued behavioural modification is advisable to avoid the reappearance of clinical signs. The long half-life of fluoxetine and its metabolites also mean that a period of at least 6 weeks should be allowed to pass before administration of any drugs which may interact adversely. |