− | Sickness behaviour, which is mediated by the release of the pro-inflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis factor-alpha. Sickness behaviour includes lethargy, depression, anorexia, energy conservation, anhedonia, cognitive impairment, hyperalgesia, decreased social interaction and anxiety. It is therefore important to be aware of this relationship between inflammation and behaviour that can contribute to signs commonly associated with emotional disorder. | + | Sickness behaviour, which is mediated by the release of the pro-inflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis factor-alpha. Sickness behaviour includes lethargy, depression, anorexia, energy conservation, anhedonia, cognitive impairment, hyperalgesia, decreased social interaction and anxiety. Many of those are signs associated with emotional disorder. It is therefore wise to consider the possibility that behavioural change is associated with medical disorder. |