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Facial and flank pheromones are used by cats to mark their core territory; an area in which cats do not expect to encounter hostility from conspecifics. Behavioural therapy involving controlled exposure is best performed in an environment where the cat already feels secure, such as within its core territory. The use of synthetic analogue of F3 (Feliway) may enhance this core territory effect, to help provide a setting within which behavioural therapy can take place. However, studies have indicated that the "calming" effect of the synthetic pheromone does not necessarily increase tolerance of handling and other procedures<ref>Kronen, P.W.,, Ludders, J.W., Erb, H.N., Moon, P.F., Gleed, R.D., Koski, S. (2006) A synthetic fraction of feline facial pheromones calms but does not reduce struggling in cats before venous catheterization. ''Vet Anaesth Analg". 33(4):258-65</ref>, so behavioural therapy must still respect the tolerance limitations of the individual cat.
 
Facial and flank pheromones are used by cats to mark their core territory; an area in which cats do not expect to encounter hostility from conspecifics. Behavioural therapy involving controlled exposure is best performed in an environment where the cat already feels secure, such as within its core territory. The use of synthetic analogue of F3 (Feliway) may enhance this core territory effect, to help provide a setting within which behavioural therapy can take place. However, studies have indicated that the "calming" effect of the synthetic pheromone does not necessarily increase tolerance of handling and other procedures<ref>Kronen, P.W.,, Ludders, J.W., Erb, H.N., Moon, P.F., Gleed, R.D., Koski, S. (2006) A synthetic fraction of feline facial pheromones calms but does not reduce struggling in cats before venous catheterization. ''Vet Anaesth Analg". 33(4):258-65</ref>, so behavioural therapy must still respect the tolerance limitations of the individual cat.
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There is some evidence that a synthetic analogue of the F4 fraction of feline facial marking pheromone [[Pheromonotherapy - Cat|(Felifriend)]] is applied to the person acting as the stooge and the environment is one in which an [[Pheromonotherapy - Cat|F3 diffuser (Feliway)]] is operating. However, F4 should be used with care as it can induce [[Feline Fear Overview|panic]] in cats that already have memories of specific aversive events involving people. These cats experience a dissonance between the visual stimulus associated with threat and danger, and the pheromone cue that signals familiarity.
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There is some evidence that a synthetic analogue of the F4 fraction of feline facial marking pheromone [[Pheromonotherapy - Cat|(Felifriend)]] may improve tolerance of approach and handling by people when applied to them<ref>Mills, D.S., Dube, M.B., Zulch, H. (2012) Stress and Pheromonatherapy in Small Animal Clinical Behaviour. Wiley-Blackwell.</ref>. However, it appears only to be effective when the cat has not already accumulated a number of aversive experiences involving the particular person and situation. These cats may experience dissonance between the visual stimulus associated with threat and danger, and the pheromone cue that signals familiarity. Pheromones like F4 should only be used in conjunction with sensitive handling and behavioural techniques<ref>Mills, D.S., Dube, M.B., Zulch, H. (2012) Stress and Pheromonatherapy in Small Animal Clinical Behaviour. Wiley-Blackwell.</ref>.
    
If the cat has already shown different levels of fear according to the appearance of the people it has encountered, then a list should be made of the features of appearance the cat tolerates least. Typically, animals least like tall people wearing dark clothing, hats or hoods, because these make them seem more threatening. This enables therapy to start with people who dress and behave in the ways that the cat is most likely to accept. A good starting point is to start with female volunteers sitting down and wearing light coloured casual clothing. Cats that show signs of fear when they hear unfamiliar voices may be desensitised to these noises using recordings or radio programmes.
 
If the cat has already shown different levels of fear according to the appearance of the people it has encountered, then a list should be made of the features of appearance the cat tolerates least. Typically, animals least like tall people wearing dark clothing, hats or hoods, because these make them seem more threatening. This enables therapy to start with people who dress and behave in the ways that the cat is most likely to accept. A good starting point is to start with female volunteers sitting down and wearing light coloured casual clothing. Cats that show signs of fear when they hear unfamiliar voices may be desensitised to these noises using recordings or radio programmes.
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