Amitriptyline also antagonises α2-adrenoceptors, which can also lead to agitation and tachycardia.
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TCAs can also cause loss of libido (breeding animals) and mild corneal drying. They can cause galactorrhea through increased prolactin secretion (especially in cats).
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Finally, those TCAs that depend upon NorAdrenaline reuptake inhibition for a part of their effect are sometimes associated with explosive emotional reactions including aggression. They should be used with some care.
'''Caution should be taken if the animal suffers from any of the following pre-existing medical conditions:'''
'''Caution should be taken if the animal suffers from any of the following pre-existing medical conditions:'''