Changes

==Alpha-casozepine==

==Alpha-casozepine==

Alpha-casozepine has been found to be extremely useful in the treatment of anxiety, where its efficacy has been shown to be on a par with selegiline<ref>Beata, C., Beaumont-Graff, E., Diaz, C., et al. Comparison of the effect of alpha-casozepine (Zylkene) versus selegiline hydrochloride on anxiety disorders in dogs. J Vet Behav 2007;2:175-83.</ref> as well as fear related behaviour<ref>Beata, C., Beaumont-Graff, E., Coll, V., et al. Effect of alpha-casozepine (Zylkene) on anxiety in cats. J Vet Behav 2007;2:40-6.</ref> in cats in conjunction with behavioural modification techniques. Alpha-casozepine is available as a supplement or as part of a commercial diet. It is a trypsin hydrolysate of alpha-S1 casein found in milk.  

Alpha-casozepine is a trypsin hydrolysate of bovine milk casein with anxiolytic and anti-epileptic effects in laboratory rodent models<ref>Miclo, L.,  Perrin, E., Driou, A., Papadopoulos, V., Boujrad, N., Vanderesse, R., Boudier, J.F., Desor, D., Linden, G., Gaillard, J.L. (2001) Characterization of α-casozepine, a tryptic peptide from

bovine αs1-casein with benzodiazepine-like activity. FASEB J.15(10):1780-2.</ref>. It has been shown to have potential anxiolytic effects in cats and dogs in two open label trials<ref>Beata, C., Beaumont-Graff, E., Diaz, C., et al. Comparison of the effect of alpha-casozepine (Zylkene) versus selegiline hydrochloride on anxiety disorders in dogs. J Vet Behav 2007;2:175-83.</ref> <ref>Beata, C., Beaumont-Graff, E., Coll, V., et al. Effect of alpha-casozepine (Zylkene) on anxiety in cats. J Vet Behav 2007;2:40-6.</ref>. However, only one of these studies included a control group, the inclusion criteria were very broad, the populations small and outcomes were measured using questionnaires that had not been validated or checked for test-retest reliability. More studies are required to confirm clinical efficacy.

==Cognitive Boosters==

==Cognitive Boosters==