− | No drugs are licensed to treat FCD, however [[Selegiline|selegiline]]<ref>Landsberg G. Therapeutic options for cognitive decline in senior pets. J Am Anim Hosp Assoc 2006; 42:407–13.</ref> and propentofylline are sometimes used unlicensed. Serotonergic drugs, such as clomipramine, may be used to reduce anxiety in cats that show predominantly emotional changes with minimal reduction in cognitive function, drugs such as selegiline may be used when cognitive impairment is the predominant feature. There is little peer reviewed evidence supporting the clinical efficacy of [[Effect of Diet on Behaviour|dietary modification]] and [[Nutraceuticals in Behaviour|supplementation]] in FCD, but diets and supplements including elevated levels of antioxidants, carnitine, phosphatidylserine, arginine, B vitamins and fish oils are commercially promoted for the treatment of FCD based on effects in dogs and laboratory animals. | + | No drugs are licensed to treat FCD, however [[Selegiline|selegiline]]<ref>Landsberg G. Therapeutic options for cognitive decline in senior pets. J Am Anim Hosp Assoc 2006; 42:407–13.</ref> and propentofylline are sometimes used unlicensed. Serotonergic drugs, such as fluoxetine or clomipramine, may be used to reduce anxiety in cats that show predominantly emotional changes with minimal reduction in cognitive function, drugs such as selegiline may be used when cognitive impairment is the predominant feature. It is important to note that selegiline must not be used concurrently with an SRI/SSRI drug, and that there should be a 2-week washout between the use of these drug types in order to avoid serotonin syndrome. There is little peer reviewed evidence supporting the clinical efficacy of [[Effect of Diet on Behaviour|dietary modification]] and [[Nutraceuticals in Behaviour|supplementation]] in FCD, but diets and supplements including elevated levels of antioxidants, carnitine, phosphatidylserine, arginine, B vitamins and fish oils are commercially promoted for the treatment of FCD based on effects in dogs and laboratory animals. |