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Sexual Differentiation - Anatomy & Physiology (view source)
Revision as of 10:14, 3 July 2008
, 10:14, 3 July 2008→Internal Genetalia
* Within the stromal tissue, cells condense into clusters to form specialized endocrine units - the interstitial '''Leydig Cells'''
* Within the stromal tissue, cells condense into clusters to form specialized endocrine units - the interstitial '''Leydig Cells'''
'''FEMALE'''
* At the time the male gonad is undergoing marked changes under the direction of SRY, the female gonad continues to appear indifferent and does not express SRY.
* Small clusters of mesenchyme surround the germ cells to initiate formation of '''Primary Follicles''', characteristic of the Ovary.
* In follicles:
** '''Mesenchymal cells''' give rise to '''Granulosa cells'''
** '''Germ cells''' give rise to '''Oocytes'''
'''''Foetal sex differentiation'''''
* Endocrine activity of the Ovaries is NOT essential for sex differentiation during foetal life, abnormal ovarian development will have no effect until puberty.
* Testes secrete two essential hormones:
** '''Steroidal hormones''' (mainly C19 androgens) from '''Leydig cells'''
** '''Mullarian Inhibiting Hormone''' (MIH) also known as '''Anti-Mullarian Hormone''' (AMH) from '''Sertoli Cells'''
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