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New page: '''''Aetiology''''' * Genotype XY as should be in the male. * Testes develop normally and secrete Androgens and MIH * Foetal genetalia are genetically insensitive to the actions of Androg...
'''''Aetiology'''''
* Genotype XY as should be in the male.
* Testes develop normally and secrete Androgens and MIH
* Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
'''''Consequence'''''
* Wolffian Ducts regress, allowing formation of '''female external genetalia''':
** Labia
** Clitoris
** Vagina
* Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
* Since both Wolffian AND Mullarian Ducts regress, there is '''no internal genetalia'''.
* Genotype XY as should be in the male.
* Testes develop normally and secrete Androgens and MIH
* Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
'''''Consequence'''''
* Wolffian Ducts regress, allowing formation of '''female external genetalia''':
** Labia
** Clitoris
** Vagina
* Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
* Since both Wolffian AND Mullarian Ducts regress, there is '''no internal genetalia'''.