Changes

The blocking ratio indicates the relative effect of the agent on reuptake of 5-HT vs. noradrenaline. Fluoxetine is 3 times more selective for 5-HT than clomipramine. Clomipramine is the only TCA that whose ratio favours 5-HT reuptake inhibition, and hence its title of non-selective serotonin reuptake inhibitor (SRI).

The blocking ratio indicates the relative effect of the agent on reuptake of 5-HT vs. noradrenaline. Fluoxetine is 3 times more selective for 5-HT than clomipramine. Clomipramine was the first TCA whose ratio favours 5-HT reuptake inhibition, and hence its title of non-selective serotonin reuptake inhibitor (SRI).

 

In cases where animals experience sedation or other unwanted side effects awareness of the intermediate metabolites can be essential. This is because when treated with the intermediate compound on its own, animals may respond better and with fewer adverse side effects<ref name="Overall1" />.

==Use==

==Use==