Amitriptyline also antagonises α2-adrenoceptors, which can lead to agitation and tachycardia.
Amitriptyline also antagonises α2-adrenoceptors, which can lead to agitation and tachycardia.
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TCAs can also cause loss of libido (breeding animals) and mild corneal drying. They can cause galactorrhea through increased prolactin secretion (especially in cats).
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TCAs can also cause loss of libido (breeding animals) and mild corneal drying. They can cause galactorrhea through increased prolactin secretion (especially in cats). TCAs that predominantly alter noradrenaline re-uptake inhibition may predispose patients to sudden and violent emotional reactions including aggression and should be used with care in aggression cases.
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Finally, those TCAs that depend upon NorAdrenaline reuptake inhibition for a part of their effect are sometimes associated with explosive emotional reactions including aggression. They should be used with some care.
There are large differences in selectivity of re-uptakje inhibitor drugs, as can be seen in the following table.
There are large differences in selectivity of re-uptakje inhibitor drugs, as can be seen in the following table.