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Selective Serotonin Reuptake Inhibitors (Clomipramine, Fluoxetine) (view source)
Revision as of 12:59, 12 September 2014
, 12:59, 12 September 2014→Serotonin syndrome
===Serotonin syndrome===
===Serotonin syndrome===
If an SRI, SSRI or TCA is overdosed or combined with another serotonergic drug (see above) an increased level of sedation and adverse effects will be observed. There is also the possibility of serotonin syndrome, especially if one of these drugs is given with an MAOI (e.g. selegiline)<ref>Haddad, P.M., Anderson, I.A. (2007) Recognising and managing antidepressant discontinuation symptoms. Advances in Psychiatric Treatment. 13, 447-457</ref>.. Signs include:
If an SRI, SSRI or TCA is overdosed or combined with another serotonergic drug (see above) an increased level of sedation and adverse effects will be observed. There is also the possibility of serotonin syndrome, especially if one of these drugs is given with an MAOI (e.g. selegiline)<ref>Haddad, P.M., Anderson, I.A. (2007) Recognising and managing antidepressant discontinuation symptoms. Advances in Psychiatric Treatment. 13, 447-457</ref>. Signs include:
*Gastrointestinal distress
*Gastrointestinal distress
*Head pain
*Head pain
Any adverse reaction should be reported via the NOAH reporting system.
Any adverse reaction should be reported via the NOAH reporting system.
===Drug withdrawal===
In humans, sudden withdrawal of SRI/SSRI/TCA drugs is associated with dysphoria, agitation, increased anxiety, relapse of psychiatric symptoms and, in some cases discontinuation syndrome.
===Drug withdrawal===
===Drug withdrawal===