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Selective Serotonin Reuptake Inhibitors (Clomipramine, Fluoxetine) (view source)
Revision as of 13:15, 12 September 2014
, 13:15, 12 September 2014→Adverse EffectsWiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.
==Adverse Effects<ref>Wiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.</ref>==
==Adverse Effects<ref>Wiersma, J., Honig, A. & Peters, F. P. J. (2000). Clomipramine-induced allergic hepatitis: a case report. International Journal of Psychiatry in Clinical Practice 4, 69–71.</ref>==
Adverse effects of these drugs include:
*Decreased appetite
*Depression/lethargy
*Shaking/shivering/tremor
*Vomiting and diarrhoea
*Restlessness and anxiety
*Seizures
*Aggression
*Mydriasis
*Vocalisation
*Weight loss
*Panting
*Confusion
*Incoordination
*Hypersalivation
However, the level and incidence of adverse effects varies considerably between drugs, with more selective drugs generally producing fewer adverse effects.
The main adverse effects of this group of drugs is mediated through their effect on histamine (H1) and muscarinic (M1) acetylcholine receptors, as summarised in the table below.
The main adverse effects of this group of drugs is mediated through their effect on histamine (H1) and muscarinic (M1) acetylcholine receptors, as summarised in the table below.