* Routine anthelmintic treatment and symptomatic care - see [[Strongyles - Donkey#Treatment|treatment of strongyles]]
* Routine anthelmintic treatment and symptomatic care - see [[Strongyles - Donkey#Treatment|treatment of strongyles]]
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Anthelmitics that have demonstrated efficacy against larval and adult ''O. equi'' in horses include ivermectin, moxidectin, fenbendazole and mebendazole. Pyrantel has demonstrated efficacy against adult stages only.
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Recently there have been a number of unpublished and some published reports of reduced anthelmintic efficacy against O. equi in horses. The Donkey Sanctuary has also experienced a lack of response to treatment with both ivermectin and pyrantel in donkeys. Therefore, this must be taken into consideration while treating.
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In addition to anthelmintic treatment, where animals are showing clinical signs such as clumps of eggs in the perineum, it is advisable to clean up the perianal region and underside of the tail using disposable cloth to remove egg masses.