Changes

==Introduction==

==Introduction==

The term "NSAIDs" stands for non-steroidal anti-inflammatory drugs. They were originially obtained from plant extracts such as willow bark, which contain agents known as salicylates. Aspirin was synthesised for the first time in 1893, and in 1972 the mode of NSAID action was discovered to be associated with cyclo-oxygenase inhibition.

The term "NSAIDs" stands for non-steroidal anti-inflammatory drugs. They were originially obtained from plant extracts such as willow bark, which contain agents known as salicylates. Aspirin was synthesised for the first time in 1893, and in 1972 the mode of NSAID action was discovered to be associated with cyclo-oxygenase (COX) inhibition. There are three categories of clinically used NSAIDs: non-selective COX inhibitors, preferential COX-2 inhibitors, and specific COX-2 inhibitors. In short, they decrease the production of prostaglandins and thromboxanes, which are inflammatory mediators. NSAIDs are widely used since they are multi-purpose drugs that do not induce addiction. Such uses include pain relief, fever reduction, and inflammation management.

==Mechanism of Action==

==Mechanism of Action==