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* [[Endocrine System - Pituitary Gland - Anatomy & Physiology #Posterior Pituitary Gland| ADH]]  causes these vesicles to attach to the principal cell membranes.
 
* [[Endocrine System - Pituitary Gland - Anatomy & Physiology #Posterior Pituitary Gland| ADH]]  causes these vesicles to attach to the principal cell membranes.
 
* This is how ADH works.   
 
* This is how ADH works.   
** The higher its concentration the more AQP2 avaiable to water within the collecting duct
+
** The higher its concentration the more AQP2 bind to principal cell membranes therefore the more AQP2 available to water within the collecting duct
 
** The more water is reabsorbed
 
** The more water is reabsorbed
 
** Thanks to the gradient created by the hypertonic medulla which is present due to the countercurrent multiplier in the [[Loop Of Henle - Anatomy & Physiology| Loop of Henle]]
 
** Thanks to the gradient created by the hypertonic medulla which is present due to the countercurrent multiplier in the [[Loop Of Henle - Anatomy & Physiology| Loop of Henle]]
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