Changes

==5. Toxicity==

==5. Toxicity==

There are no published reports of acute or chronic toxicity of any branched-chain amino acid in dogs. In contrast, in cats there is evidence that feeding high doses of leucine can result in decreased plasma concentrations of other plasma amino acids and cause a depression of growth rate in kittens<ref>Hargrove DM, et al. Effects of dietary excess of branched-chain amino acids on growth food intake and plasma amino acid concentrations of kittens. J Nutr 1988;118:311-320.</ref>. Leucine controls degradation of all branched-chain amino acids and prevents toxicity with high intake<ref name"Harris"/>.

There are no published reports of acute or chronic toxicity of any branched-chain amino acid in dogs. In contrast, in cats there is evidence that feeding high doses of leucine can result in decreased plasma concentrations of other plasma amino acids and cause a depression of growth rate in kittens<ref>Hargrove DM, et al. Effects of dietary excess of branched-chain amino acids on growth food intake and plasma amino acid concentrations of kittens. J Nutr 1988;118:311-320.</ref>. Leucine controls degradation of all branched-chain amino acids and prevents toxicity with high intake<ref name="Harris"/>.

==6. Dietary Sources==

==6. Dietary Sources==