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[http://www.feliway.com Feliway] is a synthetic analogue of the F3 fraction of the feline facial marking pheromone. It may be used to reduce general anxiety in stressful situations<ref>C.A. Griffith, E.S. Steigerwald, C.A.T. Buffington. Effects of a synthetic facial pheromone on behavior of cats. J Am Vet Med Assoc, 217 (2000), pp. 1154–1156</ref><ref>Y. Kakuma, J. Bradshaw. Effects of a feline facial pheromone analogue on stress in shelter cats: Proceedings of the 3rd International Congress on Veterinary Behavioural Medicine. British Columbia, Vancouver (2001), pp. 218–220</ref> (such as moving house, transport, presence of other animals) so that the home or environment is less threatening. It has been particularly beneficial in cases of mild-moderate cat to cat aggression within the same household<ref>Heath, S. Feline aggression. In: Horwitz D., Mills, D., Heath, S. editors. BSAVA manual of canine and feline behavioural medicine. 1st edition. Gloucester (UK) : BSAVA; 2002. p. 216-28.</ref> and in supporting cohabitation and alleviating tension in multicat households. It is thought to provide a sense of reassurance for cats in new or stressful circumstances. F3 can also be used to help control urine spraying in the home by cats <ref>Mills, D.S., Mills C.B. Evaluation of a novel method for delivering a synthetic analogue of feline facial pheromone to control urine spraying by cats. Veterinary Record 2001;149:197-199 doi:10.1136/vr.149.7.197</ref><ref>W. Hunthausen. Evaluating a feline facial pheromone analogue to control urine spraying.Vet Med, 95 (2000), pp. 151–155</ref><ref>D.F. Frank, H.N. Erb, K.A. Houpt. Urine spraying in cats: presence of concurrent disease and effects of a pheromone treatment. Appl Anim Behav Sci, 61 (1999), pp. 263–272</ref>.

[http://www.feliway.com Feliway] is a synthetic analogue of the F3 fraction of the feline facial marking pheromone. It may be used to reduce general anxiety in stressful situations<ref>C.A. Griffith, E.S. Steigerwald, C.A.T. Buffington. Effects of a synthetic facial pheromone on behavior of cats. J Am Vet Med Assoc, 217 (2000), pp. 1154–1156</ref><ref>Y. Kakuma, J. Bradshaw. Effects of a feline facial pheromone analogue on stress in shelter cats: Proceedings of the 3rd International Congress on Veterinary Behavioural Medicine. British Columbia, Vancouver (2001), pp. 218–220</ref> (such as moving house, transport, presence of other animals) so that the home or environment is less threatening. It has been particularly beneficial in cases of mild-moderate cat to cat aggression within the same household<ref>Heath, S. Feline aggression. In: Horwitz D., Mills, D., Heath, S. editors. BSAVA manual of canine and feline behavioural medicine. 1st edition. Gloucester (UK) : BSAVA; 2002. p. 216-28.</ref> and in supporting cohabitation and alleviating tension in multicat households. It is thought to provide a sense of reassurance for cats in new or stressful circumstances. F3 can also be used to help control urine spraying in the home by cats <ref>Mills, D.S., Mills C.B. Evaluation of a novel method for delivering a synthetic analogue of feline facial pheromone to control urine spraying by cats. Veterinary Record 2001;149:197-199 doi:10.1136/vr.149.7.197</ref><ref>W. Hunthausen. Evaluating a feline facial pheromone analogue to control urine spraying.Vet Med, 95 (2000), pp. 151–155</ref><ref>D.F. Frank, H.N. Erb, K.A. Houpt. Urine spraying in cats: presence of concurrent disease and effects of a pheromone treatment. Appl Anim Behav Sci, 61 (1999), pp. 263–272</ref>.

The use of F3 diffusers (Feliway) can simulate the effect of dense facial and flank marking within an environment, whilst the cats re-establish their own marks and exchange odours that identify them, usually a behaviour carried out when the cat feels relaxed in their environment<ref>P. Pageat, E. Gaultier. Current research in canine and feline pheromones. Vet Clin N Am (Small Anim Pract), 33 (2003), pp. 187–211</ref>. In a recent meta-analysis of treatments for feline urine spray marking in the home, Feliway was found to produce a 90% reduction in spraying after a 4 week period<ref>Mills, D.S., Redgate, S.E., Landsberg, G.M. (2011) A Meta-Analysis of Studies of Treatments for Feline Urine Spraying. PlosOne. 6(4), 1-10.</ref>.

The use of F3 diffusers (Feliway) can simulate the effect of dense facial marking within an environment, whilst the cats re-establish their own marks and exchange odours that identify them, usually a behaviour carried out when the cat feels relaxed in their environment<ref>P. Pageat, E. Gaultier. Current research in canine and feline pheromones. Vet Clin N Am (Small Anim Pract), 33 (2003), pp. 187–211</ref>. In a recent meta-analysis of treatments for feline urine spray marking in the home, Feliway was found to produce a 90% reduction in spraying after a 4 week period<ref>Mills, D.S., Redgate, S.E., Landsberg, G.M. (2011) A Meta-Analysis of Studies of Treatments for Feline Urine Spraying. PlosOne. 6(4), 1-10.</ref>.

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