Naturally occurring biotin deficiencies have not been reported unless accompanied by the feeding of raw egg white. Egg white contains a compound called avadin, which irreversibly binds biotin making it unavailable for physiologic use. | Naturally occurring biotin deficiencies have not been reported unless accompanied by the feeding of raw egg white. Egg white contains a compound called avadin, which irreversibly binds biotin making it unavailable for physiologic use. |