Changes

==Roles in the Body==

==Roles in the Body==

Biotin is an essential component of 4 carboxylase enzymes<ref>Sweetman L. Pantothenic Acid and Biotin. In Biochemical and physiological aspects of human nutrition. 2000 Philadelphia, PA: WB Saunders Company p.529-540.</ref>:

Biotin is an essential component of 4 carboxylase enzymes<ref>Sweetman L. Pantothenic Acid and Biotin. In Biochemical and physiological aspects of human nutrition. 2000 Philadelphia, PA: WB Saunders Company p.529-540.</ref>:

#Pyruvate carboxylase, which converts pyruvate to oxaloacetate (OAA) during carbohydrate metabolism;  

#'''Pyruvate carboxylase''', which converts pyruvate to oxaloacetate (OAA) during carbohydrate metabolism;  

#Acetyl CoA carboxylase, which is the rate limiting enzyme step in conversion of acetyl CoA to malonyl CoA in fatty acid synthesis;  

#'''Acetyl CoA carboxylase''', which is the rate limiting enzyme step in conversion of acetyl CoA to malonyl CoA in fatty acid synthesis;  

#Propionyl CoA carboxylase, which carboxylates propionyl CoA (from amino acid, fatty acid or carbohydrate metabolism) into methylmalonyl CoA; and  

#'''Propionyl CoA carboxylase''', which carboxylates propionyl CoA (from amino acid, fatty acid or carbohydrate metabolism) into methylmalonyl CoA; and  

# 3-methylcrotonyl CoA carboxylase, which functions in the catabolic pathway for leucine.

# '''3-methylcrotonyl CoA carboxylase''', which functions in the catabolic pathway for leucine.

==Consequences of Biotin Deficiency==

==Consequences of Biotin Deficiency==