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==What is Vitamin B₆ (Pyridoxine)?==

==What is Vitamin B₆ (Pyridoxine)?==

Vitamin B₆, also commonly called '''pyridoxine''', is an '''essential water-soluble vitamin''' used as a cofactor in a number of enzymatic reactions. Vitamin B₆ in the diet is found as pyridoxine, pyridoxal, and pyridoxamine all of which are hydrolysed by a phosphatase before absorption across the intestinal mucosa by passive diffusion. Once within the enterocyte the hydrolysed vitamin B₆ derivative is phosphorylated by pyridoxine kinase and transported to the liver for continued metabolism to its '''active form, pyridoxal-5-phosphate (PLP)'''. In the liver PLP is bound to albumin and then transported to target tissues. Large concentrations of pyridoxine are found in muscle, but this depot is not available during periods of Vitamin B₆ deficiency and is only released during muscle catabolism. Vitamin B₆ derivatives are freely filtered by the renal tubules.  

Vitamin B₆, also commonly called '''pyridoxine''', is an '''essential water-soluble vitamin''' used as a [[Nutrition Glossary#Cofactor|cofactor]] in a number of enzymatic reactions. Vitamin B₆ in the diet is found as pyridoxine, pyridoxal, and pyridoxamine all of which are hydrolysed by a phosphatase before absorption across the intestinal mucosa by passive diffusion. Once within the enterocyte the hydrolysed vitamin B₆ derivative is phosphorylated by pyridoxine kinase and transported to the liver for continued metabolism to its '''active form, pyridoxal-5-phosphate (PLP)'''. In the liver PLP is bound to albumin and then transported to target tissues. Large concentrations of pyridoxine are found in muscle, but this depot is not available during periods of Vitamin B₆ deficiency and is only released during muscle catabolism. Vitamin B₆ derivatives are freely filtered by the renal tubules.  

==Why is it Important?==

==Why is it Important?==