Changes

==What is Choline?==

==What is Choline?==

'''Choline''', also referred to as '''vitamin B₄''', is considered an '''essential vitamin-like substance for dogs and cats'''. It is '''soluble in water''' and often included with B vitamin supplement mixtures. Most animals are able to synthesise some choline endogenously during degradation of phospholipids in the liver. Free choline is release during metabolism of phosphotidylcholine and sphingomyelin, which can then be reincorporated into a new phospholipid or used as choline or the choline metabolite, betaine<ref>Zeisel SH. Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements. World Rev Nutr Diet 2010;101:73-83. </ref><ref name="NRC">National Research Council (NRC). Vitamins. In Nutrient Requirements for Dogs and Cats. 2006 Washington, DC: National Academies Press p.231-234.</ref>.

'''Choline''', also referred to as '''vitamin B₄''', is considered an '''essential vitamin-like substance for dogs and cats'''. It is '''soluble in water''' and often included with B vitamin supplement mixtures. Most animals are able to synthesise some choline endogenously during degradation of phospholipids in the [[Liver - Anatomy & Physiology|liver]]. Free choline is released during metabolism of phosphotidylcholine and sphingomyelin, which can then be reincorporated into a new phospholipid or used as choline or the choline metabolite, betaine<ref>Zeisel SH. Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements. World Rev Nutr Diet 2010;101:73-83. </ref><ref name="NRC">National Research Council (NRC). Vitamins. In Nutrient Requirements for Dogs and Cats. 2006 Washington, DC: National Academies Press p.231-234.</ref>.

==Why is it Important?==

==Why is it Important?==

==Roles in the Body==

==Roles in the Body==

#'''Methyl Transfer''': Choline contains three methyl groups (compared to one in s-adenosylmethionine or methionine), and its active metabolite betaine will acts as a methyl donor in reactions such as the conversion of homocysteine to methionine. The requirement for choline is influenced by total methyl group metabolism and the intake of other methyl containing compounds, such as s-adenosylmethionine and betaine.

#'''Methyl Transfer''': Choline contains three methyl groups (compared to one in s-adenosylmethionine or [[Methionine and Cysteine - Nutrition|methionine]]), and its active metabolite betaine acts as a methyl donor in reactions such as the conversion of homocysteine to methionine. The requirement for choline is influenced by total methyl group metabolism and the intake of other methyl containing compounds, such as s-adenosylmethionine and betaine.

#'''Phospholipid''': Phosphotidylcholine is one of the most abundant membrane phospholipids in the body. It provides structure to cellular membranes and is required for the formation of very low-density lipoproteins (VLDL) in the liver. Phospholipids are also involved in signal transduction between cells.  

#'''Phospholipid''': Phosphotidylcholine is one of the most abundant membrane phospholipids in the body. It provides structure to cellular membranes and is required for the formation of very low-density lipoproteins (VLDL) in the liver. Phospholipids are also involved in signal transduction between cells.  

#'''Neurotransmitter''': A small fraction of the daily choline needs are for further acetylated to form acetylcholine.

#'''Neurotransmitter''': A small fraction of the daily choline needs are further acetylated to form acetylcholine.

==Consequences of Choline Deficiency==

==Consequences of Choline Deficiency==

Choline requirements are dependent on other methyl containing dietary compounds, such as [[Methionine and Cysteine - Nutrition|methionine]], Vitamin B₁₂, folate, and lecithin (phosphotidylcholine).  

Choline requirements are dependent on other methyl containing dietary compounds, such as [[Methionine and Cysteine - Nutrition|methionine]], [[Vitamin B12 (Cobalamin) - Nutrition|Vitamin B₁₂]], folate, and lecithin (phosphotidylcholine).  

====Dogs:====  

====Dogs:====  

Puppies fed a choline deficient diet developed fatty accumulation within the liver; death occurred within 3 weeks of initiating feeding a choline deficient diet. Adult dogs fed choline deficient diets can develop hypocholesterolaemia, experience increased liver enzyme activities, vomiting, and fatty liver<ref name="NRC"/>.

Puppies fed a choline deficient diet developed fatty accumulation within the liver; death occurred within 3 weeks of initiating feeding a choline deficient diet. Adult dogs fed choline deficient diets can develop hypocholesterolaemia, experience increased liver enzyme activities, [[vomiting]], and fatty liver<ref name="NRC"/>.

====Cats:====  

====Cats:====  

Sub-optimal intake of choline results in decreased food intake and poor growth in kittens, and hepatic lipid accumulation<ref>Anderson PA, et al. Choline-methionine interrelationships in feline nutrition. J Anim Sci 1979;49:522-527.</ref>.

Sub-optimal intake of choline results in decreased food intake and poor growth in kittens, and hepatic lipid accumulation<ref>Anderson PA, et al. Choline-methionine interrelationships in feline nutrition. J Anim Sci 1979;49:522-527.</ref>.

==Toxicity==

==Toxicity==

There are no published reports of choline toxicity in cats. Early studies in excess choline intake in dogs suggest that depressed erythrocyte formation may occur<ref name="NRC"/>.

There are no published reports of choline toxicity in cats. Early studies in excess choline intake in dogs suggest that depressed [[erythrocyte]] formation may occur<ref name="NRC"/>.

==Dietary Sources==

==Dietary Sources==

[[Category:Vitamins]]

[[Category:Vitamins]]

[[Category:To Do - Nutrition]]

[[Category:To Do - Nutrition]]

[[Category:To Do - Nutrition GGP]]

[[Category:To Do - Nutrition preMars]]