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→Recognised Syndromes Related to Selenium Deficiency
Researchers of selenium deficiency in dogs have reported clinical signs and changes in selenium status. Nevertheless, despite the role of selenium in the deiodinase enzymes, selenium deficiency did not appear to be linked to [[hypothyroidism]] in dogs<ref>Wedekind, KJ, Kirk, CA, Nachreiner, RF, Yu, S (2001). “Effect of varying selenium (Se) intake on thyroid hormone metabolism in dogs”. FASEB J. 15:A953.</ref>.
Researchers of selenium deficiency in dogs have reported clinical signs and changes in selenium status. Nevertheless, despite the role of selenium in the deiodinase enzymes, selenium deficiency did not appear to be linked to [[hypothyroidism]] in dogs<ref>Wedekind, KJ, Kirk, CA, Nachreiner, RF, Yu, S (2001). “Effect of varying selenium (Se) intake on thyroid hormone metabolism in dogs”. FASEB J. 15:A953.</ref>.
====Recognised Syndromes Related to Selenium Deficiency====
====Recognised Syndromes Related to Selenium Deficiency====
#'''Selenium depletion''': Puppies fed a diet deficient in vitamin E and selenium, (selenium content 0.01 mg/kg on a dry matter (DM) basis) developed various clinical signs including anorexia, depression, abnormal breathing and coma within 6-8 weeks. Post mortem examination revealed muscular degeneration and renal mineralisation. Even when puppies were supplemented with selenium (dietary content of 0.5 mg/kg DM), mild skeletal myopathy was observed<ref>. Van Vleet, J, (1975). “Experimentally induced vitamin E-selenium deficiency in the growing dog”. J. Am. Vet. Med. Assoc. 166:769-774.</ref>.
#'''Selenium depletion''': Puppies fed a diet deficient in vitamin E and selenium, (selenium content 0.01 mg/kg on a [[Nutrition Glossary#Dry Matter Basis|dry matter (DM) basis]]) developed various clinical signs including anorexia, depression, abnormal breathing and coma within 6-8 weeks. Post mortem examination revealed muscular degeneration and renal mineralisation. Even when puppies were supplemented with selenium (dietary content of 0.5 mg/kg DM), mild skeletal myopathy was observed<ref>. Van Vleet, J, (1975). “Experimentally induced vitamin E-selenium deficiency in the growing dog”. J. Am. Vet. Med. Assoc. 166:769-774.</ref>.
#'''Serum selenium''': Purified diets containing a selenium content of less than 0.21 mg/kg DM were insufficient to support normal serum selenium concentrations in 9-week-old beagle puppies<ref name="Wedekind">Wedekind, KJ, Combs Jr, GF (2000). “Selenium in petfoods: Is bioavailability an issue?”. Compend. Contin. Educ. Pract. Vet. 22(suppl.):17-22.</ref>.
#'''Serum selenium''': Purified diets containing a selenium content of less than 0.21 mg/kg DM were insufficient to support normal serum selenium concentrations in 9-week-old beagle puppies<ref name="Wedekind">Wedekind, KJ, Combs Jr, GF (2000). “Selenium in petfoods: Is bioavailability an issue?”. Compend. Contin. Educ. Pract. Vet. 22(suppl.):17-22.</ref>.