Changes

Cats and kittens fed niacin deficient diets develop anorexia, fever, erythema of oral mucosa and tongue with eventual ulceration, weight loss, and death within the 2-3 weeks.<ref>Heath MK, ''et al.'' (1940)''' Feline pellagra.''''' Science ''1940;92:514;</ref><ref>Da Silva AC, ''et al.'' (1952)''' The domestic cat as laboratory animal for experimental nutrition studies. II Niacin requirement and tryptophan metabolism.''''' J Nutr'' 1952;1:26-32.</ref>

Cats and kittens fed niacin deficient diets develop anorexia, fever, erythema of oral mucosa and tongue with eventual ulceration, weight loss, and death within the 2-3 weeks.<ref>Heath MK, ''et al.'' (1940)''' Feline pellagra.''''' Science ''1940;92:514;</ref><ref>Da Silva AC, ''et al.'' (1952)''' The domestic cat as laboratory animal for experimental nutrition studies. II Niacin requirement and tryptophan metabolism.''''' J Nutr'' 1952;1:26-32.</ref>

Niacin is prone to degradation with heat processing. Conditions associated with diuresis (e.g. chronic disease, such as renal disease or [[Diabetes Insipidus|diabetes]], or therapeutic intervention, such as intravenous fluids or increased water intake with management of [[Cystitis|lower urinary diseases]]) can result in increased loss of niacin and may increase daily requirements. Patients on chronic haemodialysis are at an increased risk of developing a deficiency.

Niacin is prone to degradation with heat processing. Conditions associated with diuresis (e.g. chronic disease, such as [[:Category:Kidney - Pathology|renal disease]] or [[Diabetes Insipidus|diabetes]], or therapeutic intervention, such as [[Fluid therapy|intravenous fluids]] or increased water intake with management of [[Cystitis|lower urinary diseases]]) can result in increased loss of niacin and may increase daily requirements. Patients on chronic haemodialysis are at an increased risk of developing a deficiency.

==Toxicity==

==Toxicity==