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==What is Vitamin B5 (Pantothenic Acid)?==

==What is Vitamin B5 (Pantothenic Acid)?==

Vitamin B₅, also called pantothenic acid, is an '''essential water-soluble vitamin used in energy metabolism'''. Pantothenic acid is an integral component of [[Nutrition Glossary#Coenzyme|coenzyme]] A, which is synthesised in animals by a series of steps that involve the initial phosphorylation to pantothenic acid 4' -phosphate catalysed by pantothenate kinase, the primary regulatory step of Coenzyme A (CoA) synthesis<ref name="Plesofsky">Plesofsky N.S. (2001) Pantothenic acid. In Handbook of Vitamins. Third ed. Rucker, R. B., J.W. Suttie, D. B. McCormick and 1. J. Machlin ed. pp 317-337. New York: Marcel Dekker, Inc.</ref>. Dietary pantothenic acid is widely distributed in many foods, and is normally found as a component of CoA, acyl-CoA synthetase, or acyl carrier proteins. All of these forms are hydrolysed to pantothenic acid within the intestinal lumen prior to being absorbed by carrier mediated transport across the mucosa. Pantothenic acid is then transported in blood bound to [[Erythrocyte|red blood cells]] to target tissues. Pantothenic acid is filtered by the [[Nephron Microscopic Anatomy#Proximal Tubule|renal tubules]], with active reabsorption during periods of low intake<ref name="Silber">Silber RH. Studies of pantothenic acid deficiency in dogs. J Nutr 1944;27:425-433.</ref>.

Vitamin B₅, also called pantothenic acid, is an '''[[Nutrition Glossary#Essential Nutrients|essential]] water-soluble vitamin used in energy metabolism'''. Pantothenic acid is an integral component of [[Nutrition Glossary#Coenzyme|coenzyme]] A, which is synthesised in animals by a series of steps that involve the initial phosphorylation to pantothenic acid 4' -phosphate catalysed by pantothenate kinase, the primary regulatory step of Coenzyme A (CoA) synthesis<ref name="Plesofsky">Plesofsky N.S. (2001) Pantothenic acid. In Handbook of Vitamins. Third ed. Rucker, R. B., J.W. Suttie, D. B. McCormick and 1. J. Machlin ed. pp 317-337. New York: Marcel Dekker, Inc.</ref>. Dietary pantothenic acid is widely distributed in many foods, and is normally found as a component of CoA, acyl-CoA synthetase, or acyl carrier proteins. All of these forms are hydrolysed to pantothenic acid within the intestinal lumen prior to being absorbed by carrier mediated transport across the mucosa. Pantothenic acid is then transported in blood bound to [[Erythrocyte|red blood cells]] to target tissues. Pantothenic acid is filtered by the [[Nephron Microscopic Anatomy#Proximal Tubule|renal tubules]], with active reabsorption during periods of low intake<ref name="Silber">Silber RH. Studies of pantothenic acid deficiency in dogs. J Nutr 1944;27:425-433.</ref>.

==Why is it Important?==

==Why is it Important?==