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==What is Vitamin B₆ (Pyridoxine)?==

==What is Vitamin B₆ (Pyridoxine)?==

Vitamin B₆, also commonly called '''pyridoxine''', is an '''essential water-soluble vitamin''' used as a [[Nutrition Glossary#Cofactor|cofactor]] in a number of enzymatic reactions. Vitamin B₆ in the diet is found as pyridoxine, pyridoxal, and pyridoxamine all of which are hydrolysed by a phosphatase before absorption across the intestinal mucosa by [[Diffusion - Physiology|passive diffusion]]. Once within the enterocyte the hydrolysed vitamin B₆ derivative is phosphorylated by pyridoxine kinase and transported to the [[Liver - Anatomy & Physiology|liver]] for continued metabolism to its '''active form, pyridoxal-5-phosphate (PLP)'''. In the liver PLP is bound to [[albumin]] and then transported to target tissues. Large concentrations of pyridoxine are found in [[Muscle Development - Anatomy & Physiology|muscle]], but this depot is not available during periods of Vitamin B₆ deficiency and is only released during muscle catabolism. Vitamin B₆ derivatives are freely filtered by the [[Nephron Microscopic Anatomy#Proximal Tubule|renal tubules]].  

Vitamin B₆, also commonly called '''pyridoxine''', is an '''[[Nutrition Glossary#Essential Nutrients|essential]] water-soluble vitamin''' used as a [[Nutrition Glossary#Cofactor|cofactor]] in a number of enzymatic reactions. Vitamin B₆ in the diet is found as pyridoxine, pyridoxal, and pyridoxamine all of which are hydrolysed by a phosphatase before absorption across the intestinal mucosa by [[Diffusion - Physiology|passive diffusion]]. Once within the enterocyte the hydrolysed vitamin B₆ derivative is phosphorylated by pyridoxine kinase and transported to the [[Liver - Anatomy & Physiology|liver]] for continued metabolism to its '''active form, pyridoxal-5-phosphate (PLP)'''. In the liver PLP is bound to [[albumin]] and then transported to target tissues. Large concentrations of pyridoxine are found in [[Muscle Development - Anatomy & Physiology|muscle]], but this depot is not available during periods of Vitamin B₆ deficiency and is only released during muscle catabolism. Vitamin B₆ derivatives are freely filtered by the [[Nephron Microscopic Anatomy#Proximal Tubule|renal tubules]].

==Why is it Important?==

==Why is it Important?==