Changes

==Roles in the Body==

==Roles in the Body==

Biotin is an essential component of 4 carboxylase enzymes<ref>Sweetman L. Pantothenic Acid and Biotin. In Biochemical and physiological aspects of human nutrition. 2000 Philadelphia, PA: WB Saunders Company p.529-540.</ref>:

Biotin is an essential component of 4 carboxylase enzymes<ref>Sweetman L. Pantothenic Acid and Biotin. In Biochemical and physiological aspects of human nutrition. 2000 Philadelphia, PA: WB Saunders Company p.529-540.</ref>:

#'''Pyruvate carboxylase''', which converts pyruvate to oxaloacetate (OAA) during [[Carbohydrate Overview - Nutrition|carbohydrate]] metabolism;  

#'''Pyruvate carboxylase''', which converts pyruvate to oxaloacetate (OAA) during [[Carbohydrates Overview - Nutrition|carbohydrate]] metabolism;  

#'''Acetyl CoA carboxylase''', which is the rate limiting enzyme step in conversion of acetyl CoA to malonyl CoA in fatty acid synthesis;  

#'''Acetyl CoA carboxylase''', which is the rate limiting enzyme step in conversion of acetyl CoA to malonyl CoA in [[Fatty Acids Overview - Nutrition|fatty acid]] synthesis;  

#'''Propionyl CoA carboxylase''', which carboxylates propionyl CoA (from [[Protein Overview - Nutrition|amino acid]], [[Fatty Acids - Nutrition|fatty acid] or carbohydrate metabolism) into methylmalonyl CoA; and  

#'''Propionyl CoA carboxylase''', which carboxylates propionyl CoA (from [[Protein Overview - Nutrition|amino acid]], fatty acid or carbohydrate metabolism) into methylmalonyl CoA; and  

# '''3-methylcrotonyl CoA carboxylase''', which functions in the catabolic pathway for leucine.

# '''3-methylcrotonyl CoA carboxylase''', which functions in the catabolic pathway for [[Branched-Chain Amino Acids - Nutrition|leucine]].

==Consequences of Biotin Deficiency==

==Consequences of Biotin Deficiency==