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Vitamin B9 (Folic Acid) - Nutrition (view source)
Revision as of 09:40, 22 May 2015
, 09:40, 22 May 2015→Roles in the Body
==Roles in the Body==
==Roles in the Body==
#'''Amino Acid Metabolism''': Folic acid cofactors are used in the inter-conversion of [[Methionine and Cysteine - Nutrition#What are Methionine and Cysteine?|serine]] and [[Taurine - Nutrition#Roles in the Body|glycine]], [[Histidine - Nutrition|histidine]] catabolism, and the regeneration of [[Methionine and Cysteine - Nutrition|methionine]] via donation of a methyl group to homocysteine.<ref name ="Shane">Shane B. (2000) '''Folic Acid, Vitamin B12, and Vitamin B6. In Biochemical and physiological aspects of human nutrition. '''2000 Philadelphia, PA: WB ''Saunders Company'' p. 484-500.</ref>
#'''Amino Acid Metabolism''': Folic acid cofactors are used in the inter-conversion of [[Methionine and Cysteine - Nutrition#What are Methionine and Cysteine?|serine]] and [[Taurine - Nutrition#Roles in the Body|glycine]], [[Histidine - Nutrition|histidine]] catabolism, and the regeneration of [[Methionine and Cysteine - Nutrition|methionine]] via donation of a methyl group to homocysteine.<ref name ="Shane">Shane B. (2000) '''Folic Acid, Vitamin B12, and Vitamin B6. In Biochemical and physiological aspects of human nutrition. '''2000 Philadelphia, PA: WB ''Saunders Company'' p. 484-500.</ref>
#'''Nucleotide Synthesis''': Folic acid derivatives are required for purine synthesis and also act as cofactors for thymidylate synthase and dihydrofolate reductase used in synthesis of thymine.<ref name="Shane" /> Thymidylate synthase and dihydrofolate reductase have high expression in replicating tissue.
#'''Nucleotide Synthesis''': Folic acid derivatives are required for purine synthesis and also act as cofactors for thymidylate synthase and dihydrofolate reductase used in synthesis of [[thymine]].<ref name="Shane" /> Thymidylate synthase and dihydrofolate reductase have high expression in replicating tissue.
#'''Therapeutic Target''': The folate antagonist methotrexate, which is used to treat certain types of [[Neoplasia - Pathology|cancers]] is a selective inhibitor of dihydrofolate reductase.
#'''Therapeutic Target''': The folate antagonist methotrexate, which is used to treat certain types of [[Neoplasia - Pathology|cancers]] is a selective inhibitor of dihydrofolate reductase.