Changes

==Signalment==

==Signalment==

Giant and large breeds (e.g. Doberman Pinscher, Irish Wolfhound and Great Dane) are most at risk.  

Giant and large breeds are most at risk. Predisposed breeds include: Irish Wolfhound, Great Dane, Newfoundland, Leonberger, St. Bernard, Dobermann Pinscher, Boxer, Dogue de Bordeaux and the Portuguese Water dog.  

Prevalence increases with age and the typical age at diagnosis is 6-8 years.  

Prevalence increases with age and the typical age at diagnosis is 6-8 years. A severe juvenile form is recognized in the Portuguese Water dog.  

Male dogs are more frequently affected than females, particularly in Doberman Pinschers.

Male dogs are more frequently affected than females, particularly in Doberman Pinschers.