Changes

==== Increase Myocardial Systolic Function ====

==== Increase Myocardial Systolic Function ====

This helps with dilated cardiomyopathy and [[Mitral Valve Dysplasia|mitral valve disease]] (dog & cat) but is '''contraindicated''' in animals with [[Hypertrophic Cardiomyopathy|hypertrophic cardiomyopathy]] (dog & cat). '''Positive Inotropes''' can be used to stimulates myocardial contractility to improve cardiac output regardless of preload. This class of drug includes digitalis compounds (e.g. Digoxin, Digitoxin), calcium sensitisers/ phosphodiesterase III. inhibitor (e.g. Pimobendan), pure phosphodiesterase inhibitors (e.g. Milrinone, Amrinone) and catecholamines (e.g. Dobutamine, Dopamine).  

This helps with dilated cardiomyopathy and [[Degenerative Mitral Valve Disease|mitral valve disease]] (dog & cat) but is '''contraindicated''' in animals with [[Hypertrophic Cardiomyopathy|hypertrophic cardiomyopathy]] (dog & cat). '''Positive Inotropes''' can be used to stimulates myocardial contractility to improve cardiac output regardless of preload. This class of drug includes digitalis compounds (e.g. Digoxin, Digitoxin), calcium sensitisers/ phosphodiesterase III. inhibitor (e.g. Pimobendan), pure phosphodiesterase inhibitors (e.g. Milrinone, Amrinone) and catecholamines (e.g. Dobutamine, Dopamine).  

The disadvantage of positive inotropes is that increased myocardial work causes increased myocardial oxygen demand.  

The disadvantage of positive inotropes is that increased myocardial work causes increased myocardial oxygen demand.