Changes

EPO is transported from kidneys to [[Bone Marrow - Anatomy & Physiology|bone marrow]] where it acts upon receptors on the CFU-E’s and causes differentiation into erythrocyte precursors. It also increases the rate of division and maturation of developing erythrocyte precursors by increasing the rate of gene transcription. Thus it is not the number of [[Erythrocytes|erythrocytes]] but the oxygen concentration that controls erythrocyte numbers. EPO release can be affected by any form of renal pathology. Inflammatory induced release of interleukins reduces the secretion of erythropoietin.

EPO is transported from kidneys to [[Bone Marrow - Anatomy & Physiology|bone marrow]] where it acts upon receptors on the CFU-E’s and causes differentiation into erythrocyte precursors. It also increases the rate of division and maturation of developing erythrocyte precursors by increasing the rate of gene transcription. Thus it is not the number of [[Erythrocytes|erythrocytes]] but the oxygen concentration that controls erythrocyte numbers. EPO release can be affected by any form of renal pathology. Inflammatory induced release of interleukins reduces the secretion of erythropoietin.

The mechanism of oxygen concntration detection is via HIF-1 (hypoxia inducible factor 1) which is a transcription activator that is oxygen sensitive.

The mechanism of oxygen concentration detection is via HIF-1 (hypoxia inducible factor 1) which is a transcription activator that is oxygen sensitive.

[[Category:Haematopoiesis]]

[[Category:Haematopoiesis]]