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→Pathophysiology of oxidative damage to haemoglobin
Oxidation results in three major changes to the haemoglobin molecules:
Oxidation results in three major changes to the haemoglobin molecules:
* '''Heinz bodies''' are produced when the sylfhydral groups in the '''globin part of the haemoglobin molecule''' undergoes oxidation, causing the molecule to become unstable. Heinz bodies are formed when the damaged haemoglobin molecules coalesce. <ref name="CVT">Bonagura, J and Kirk, R (eds) (1995) '''Kirk's Current Veterinary Therapy XII''' WB Saunders, p. 444</ref> In most species, Heinz bodies can be removed from erythrocytes by the spleen.
* '''Heinz bodies''' are produced when the sulfhydral groups in the '''globin part of the haemoglobin molecule''' undergoes oxidation, causing the molecule to become unstable. Heinz bodies are formed when the damaged haemoglobin molecules coalesce. <ref name="CVT">Bonagura, J and Kirk, R (eds) (1995) '''Kirk's Current Veterinary Therapy XII''' WB Saunders, p. 444</ref> In most species, Heinz bodies can be removed from erythrocytes by the spleen.
This article will cover only Heinz bodies in detail.
This article will cover only Heinz bodies in detail.
==Substances causing Heinz body formation==
==Substances causing Heinz body formation==