Changes

*Superoxide dismutase and catalase production may resist oxidative killing

*Superoxide dismutase and catalase production may resist oxidative killing

*Lymph nodes enlarge (lymphatic and lymphoreticular hyperplasia) and inflammation is induced

*Lymph nodes enlarge (lymphatic and lymphoreticular hyperplasia) and inflammation is induced

*Surviving organisms spread to other organs (liver, spleen, placenta) and cause granulomatous reactions

*Surviving organisms spread to other organs (liver, [[Spleen - Anatomy & Physiology|spleen]], placenta) and cause granulomatous reactions

*Eythritol is a growth stimulant and attracts the bacteria to the placenta of cattle, sheep, goats and pigs; also found in mammary gland and epididymis, targets for brucellae

*Eythritol is a growth stimulant and attracts the bacteria to the placenta of cattle, sheep, goats and pigs; also found in mammary gland and epididymis, targets for brucellae

*Infection of foetus and abortion

*Infection of foetus and abortion

**Seminal vesicles, ampullae, testicles and epididymus infected in bulls; necrotising orchitis

**Seminal vesicles, ampullae, testicles and epididymus infected in bulls; necrotising orchitis

**Decreased fertility in cows and bulls; decreased milk production  

**Decreased fertility in cows and bulls; decreased milk production  

**Localisation in spleen and lymphatic tissue of non-pregnant animals

**Localisation in [[Spleen - Anatomy & Physiology|spleen]] and lymphatic tissue of non-pregnant animals

**Occasionally causes [[Joints - inflammatory#In Cattle|arthritis]]

**Occasionally causes [[Joints - inflammatory#In Cattle|arthritis]]

*Isolated from closed cases of [[Bursae and Tendons - inflammatory#Poll Evil and Fistulous Withers|poll evil and fistulous withers]] in horses

*Isolated from closed cases of [[Bursae and Tendons - inflammatory#Poll Evil and Fistulous Withers|poll evil and fistulous withers]] in horses